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KMID : 0607119950020010149
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Inha Medical Journal
1995 Volume.2 No. 1 p.149 ~ p.154
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A Case of IgA Type Multiple Myeloma with Severe Bleeding Diathesis after Bone Marrow Biopsy
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김여주
박기수/정석/김선후/이진우/방제소/박재후/김진주
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Abstract
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Acquired coagulation abnormalities are frequent manifestations of dysproteinemias. The hemostatic abnormalities are varied, involving both coagulation proteins and platelets. The pathophysiologic mechanism responsible for these casgulation
defects
is an
abnormal interation between hemostatic component and plasma protein. Paraproteins are monoclonal immunoglunulins produced by plasma cell dyscrasias such as multiple myeloma. Multiple myeloma is a neoplasm of plasma cells, which produce and
secrete
immunoglubulins, proliferating in bone marrow. This, it is characterized by overproduction of monoclonal immunoglobulin(m-component) into the serum or urine. Among the variety of clinical symptoms, it has been reported that bleeding tendency
occupies
7.5% of the chief complaints of patients wit multiple myeloma and in about 40%, the bleeding tendency accompanies the patients intheir clinical course. We experienced a case of Iga type multiple myeloma developed hematoma in the right gluteus
medius
muscle and leg after bone marrow biopsy.
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